Coronary angioplasty, also known as percutaneous coronary intervention (PCI), is a common procedure used to treat blocked or narrowed coronary arteries. Traditionally, angioplasty involves the use of a stent to help keep the artery open and restore blood flow to the heart. However, a newer technique called Drug-Eluting Balloon (DEB) angioplasty has emerged as an alternative treatment option. In this blog post, we will delve into the world of DEB angioplasty, exploring its function, benefits, and its role in the field of interventional cardiology.

Understanding DEB Angioplasty:

DEB angioplasty is a minimally invasive procedure that aims to improve blood flow in narrowed or blocked arteries without the use of a stent. Instead, a special balloon catheter coated with medication is used to dilate the narrowed artery and deliver the medication directly to the affected site.

During the procedure, the DEB catheter is guided to the site of the blockage using fluoroscopy and angiography. The balloon is then inflated, compressing the plaque against the artery walls and widening the vessel. At the same time, the medication coating on the balloon is released, helping to prevent restenosis (re-narrowing) of the artery.

Benefits of DEB Angioplasty:

  • No Permanent Implant: One of the primary benefits of DEB angioplasty is that it does not require the permanent implantation of a stent. This means that patients do not have a foreign object inside their artery, which can reduce the risk of long-term complications associated with stents, such as stent thrombosis.
  • Reduced Risk of Late Complications: DEB angioplasty has shown promising results in reducing the risk of restenosis compared to bare-metal stents. The medication coating on the balloon helps to inhibit the growth of cells that can lead to re-narrowing of the artery.
  • Potential for Future Treatment Options: By avoiding the permanent implantation of a stent, DEB angioplasty preserves the option for future treatments. If needed, the artery can be accessed again for additional interventions, including the placement of a stent or other advanced procedures.
  • Minimally Invasive Procedure: DEB angioplasty is a minimally invasive procedure performed under local anesthesia. It involves a small incision for catheter insertion, resulting in shorter hospital stays, faster recovery times, and minimal scarring for patients.

Considerations and Limitations:

While DEB angioplasty offers several advantages, there are some considerations to keep in mind:

  • Patient Selection: Not all cases are suitable for DEB angioplasty. The decision to perform DEB angioplasty without a stent depends on factors such as the location and characteristics of the blockage, the size of the artery, and the patient’s overall condition. The interventional cardiologist will assess each case individually to determine the most appropriate treatment approach.
  • Restenosis Risk: Although DEB angioplasty helps reduce the risk of restenosis compared to bare-metal stents, there is still a possibility of recurrent narrowing over time. Close monitoring and follow-up care are necessary to detect any signs of restenosis and provide timely intervention if needed.


DEB angioplasty represents an innovative approach to managing blocked or narrowed arteries in interventional cardiology. By delivering medication directly to the affected site without the use of a permanent stent, DEB angioplasty offers a potentially safer and more flexible treatment option for patients. However, it is important to note that DEB angioplasty may not be suitable for all cases, and the decision to proceed with this technique should be made in collaboration between the interventional cardiologist and the patient. As the field of interventional cardiology continues to advance, DEB angioplasty holds promise for improving patient outcomes and providing personalized treatment options in the management of coronary artery disease.